CCR3 and Choroidal Neovascularization

CCR3 and Choroidal Neovascularization

Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly in industrialized countries. The "wet" AMD, characterized by the development of choroidal neovacularization (CNV), could result in rapid and severe loss of central vision. The critical role of vascular endothelial growth factor A (VEGF-A) in CNV development has been established and VEGF-A neutra...

Method of Using CCR3 Binding Agents to Detect Choroidal Neovascularization

Retinal Inhibition of CCR3 Induces Retinal Cell Death in a Murine Model of Choroidal Neovascularization

Inhibition of chemokine C-C motif receptor 3 (CCR3) signaling has been considered as treatment for neovascular age-related macular degeneration (AMD). However, CCR3 is expressed in neural retina from aged human donor eyes. Therefore, broad CCR3 inhibition may be harmful to the retina. We assessed the effects of CCR3 inhibition on retina and choroidal endothelial cells (CECs) that develop into c...

Unilateral Choroidal Osteoma with Choroidal Neovascularization

A 16 year old female presented to the New England Eye Center with a chief complaint of decreased vision and metamorphopsia in the left eye. The symptoms started three months prior to presentation and remained unchanged from onset. There were no other visual complaints at the time of presentation. She denied any prior ocular history; this was her first eye exam. On review of systems, there was n...

Current choroidal neovascularization treatment.

PURPOSE This paper aims to describe the current situation of choroidal neovascularization (CNV) treatment. PROCEDURES MEDLINE (2001-2013) was searched for original research studies (phase I, II, III), abstracts and review articles concerning CNV therapy, and other related articles. Selected information from related websites was also included. RESULTS The management of CNV was developed thro...